منابع مشابه
Complete dissipation of coherent clonal growth occurs before gastrulation in mouse epiblast.
Observations on chimaeric mice argue that there must be considerable dispersal and intermingling of the clonal descendants of epiblast founder cells at an early stage in the development of the tissue. However, it has not been established when or how this occurs. Here we have used a genetic marker that enables donor cells to be visualized in situ to examine the early postimplantation distributio...
متن کاملInappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation
Cadherin switching from E-cadherin (E-cad) to N-cadherin (N-cad) is a key step of the epithelial-mesenchymal transition (EMT) processes that occurs during gastrulation and cancer progression. We investigate whether cadherins actively participate in progression of EMT by crosstalk to signaling pathways. We apply ectopic cadherin switching before the onset of mouse gastrulation. Mutants with an i...
متن کاملA role for N-cadherin in mesodermal morphogenesis during gastrulation.
Cell adhesion molecules mediate numerous developmental processes necessary for the segregation and organization of tissues. Here we show that the zebrafish biber (bib) mutant encodes a dominant allele at the N-cadherin locus. When knocked down with antisense oligonucleotides, bib mutants phenocopy parachute (pac) null alleles, demonstrating that bib is a gain-of-function mutation. The mutant ph...
متن کاملStructural Basis of Adhesion during Gastrulation and Brain Morphogenesis
Gastrulation is a masterpiece symphony performed by specified organ progenitors undergoing coherent morphogenetic movements. The movements of epiboly, internalization, convergence and extension transform the radially symmetric blastula into the gastrula with clear dorsal-ventral (D-V) and anteriorposterior (A-P) axes. Epiboly spreads the tissue vegetal-wards; internalization separates mesoderma...
متن کاملGastrulation in the mouse: assessment of cell populations in the epiblast of tw18/tw18 embryos.
Homozygous tW18 embryos die prior to organogenesis. They develop gross abnormalities shortly after primitive streak formation. Anatomically, the lesion appears to be confined to the mesoderm with that tissue showing ultrastructural deficiencies and abnormal migration (Spiegelman & Bennett, 1974), and failing to develop in teratomas produced from mutant embryos (Artzt & Bennett, 1972). Analysis ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Developmental Biology
سال: 2015
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2014.10.003